PubMed Link

Fomenko D.E., Marino S.M., Gladyshev V.N. (2008) Functional Diversity of Cysteine Residues in Proteins and Unique Features of Catalytic Redox-Active Cysteines in Thiol Oxidoreductases. Mol Cells., 26. [Abstract]

Zhang Y., Gladyshev V.N. (2008) Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. PLoS Genet., 4, e1000095. [Abstract]

Zhang Y., Turanov A.A., Hatfield D.L., Gladyshev V.N. (2008) In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait. BMC Genomics, 9, 251. [Abstract]

Le D.T., Liang X., Fomenko D.E., Raza A.S., Chong C.K., Carlson B.A., Hatfield D.L., Gladyshev V.N. (2008) Analysis of Methionine/Selenomethionine Oxidation and Methionine Sulfoxide Reductase Function Using Methionine-Rich Proteins and Antibodies against Their Oxidized Forms. Biochemistry, May 28. [Abstract]

Shrimali R.K., Irons R.D., Carlson B.A., Sano Y., Gladyshev V.N., Park J.M., Hatfield D.L. (2008) Selenoproteins mediate T cell immunity through an antioxidant mechanism. J Biol Chem., 283, 20181-20185. [Abstract]

Zhang Y., Gladyshev V.N. (2008) Molybdoproteomes and evolution of molybdenum utilization. J Mol Biol., 379, 881-899. [Abstract]

Bonilla M., Denicola A., Novoselov S.V., Turanov A.A., Protasio A., Izmendi D., Gladyshev V.N., Salinas G. (2008) Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem., 283, 17898-17907. [Abstract]

Lobanov A.V., Hatfield D.L., Gladyshev V.N. (2008) Reduced reliance on the trace element selenium during evolution of mammals. Genome Biol., 9, R62. [Abstract]

Sengupta A., Carlson B.A., Weaver J.A., Novoselov S.V., Fomenko D.E., Gladyshev V.N., Hatfield D.L. (2008) A functional link between housekeeping selenoproteins and phase II enzymes. Biochem J., 413, 151-161. [Abstract]

Castellano S., Gladyshev V.N., Guigó R., Berry M.J. (2008) SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements. Nucleic Acids Res., 36 (Database issue), D332-338. [Abstract]

Ridge P.G., Zhang Y., Gladyshev V.N. (2008) Comparative Genomic Analyses of Copper Transporters and Cuproproteomes Reveal Evolutionary Dynamics of Copper Utilization and Its Link to Oxygen. PLOS ONE, 3, e1378 [Abstract]

Sengupta A., Carlson B.A., Hoffmann V.J., Gladyshev V.N., Hatfield D.L. (2008) Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism. Biochem Biophys Res Commun., 365, 446-452. [Abstract] [Link]

Lobanov A.V., Hatfield D.L., Gladyshev V.N. (2008) Selenoproteinless animals: Selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Protein Sci., 17, 176-182. [Abstract]

Ganichkin O.M., Xu X.M., Carlson B.A., Mix H., Hatfield D.L., Gladyshev V.N., Wahl M.C. (2008) Structure and catalytic mechanism of eukaryotic selenocysteine synthase. J Biol Chem., 283, 5849-5865. [Abstract]

Zhang Y., Zhou Y., Schweizer U., Savaskan N.E., Hua D., Kipnis J., Hatfield D.L., Gladyshev V.N. (2008) Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals. J Biol Chem., 283, 2427-2438. [Abstract]

Redox Biochemistry. (ed., Banerjee R.; assoc. ed., Gladyshev V.N., Ragsdale S.W., Becker D.F., Dickman M.B.), John Wiley & Sons, 2007 [Purchase]
See commentary in: Wood M.J. (2008) Refocusing redox biochemistry. Nature Chemical Biology, 4, 267. [Commentary]

Yoo M.H., Xu X.M., Carlson B.A., Patterson A.D., Gladyshev V.N., Hatfield D.L. (2007) Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication. PLoS ONE, 2, e1112. [Abstract]

Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J., Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L., Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H., Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M., Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L., Cognat V., Croft M.T., Dent R, Dutcher S., Fernandez E., Fukuzawa H., Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M., Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A., Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L., Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C., Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G., Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L., Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L., Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C., Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J., Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P., Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R., Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P., Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y., Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L., Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R. (2007) The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science, 318, 245-250. [Abstract]

Aachmann F.L., Fomenko D.E., Soragni A., Gladyshev V.N., Dikiy A. (2007) Structural analysis of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins. J Biol Chem., 282, 37036-37044. [Abstract]

Kim H.Y., Gladyshev V.N. (2007) Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals. Biochem J., 407, 321-329. [Abstract]

Lobanov A.V., Fomenko D.E., Zhang Y., Sengupta A., Hatfield D.L., Gladyshev V.N. (2007) Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic and small with terrestrial life. Genome Biol., 8, R198. [Abstract]

Carlson B.A., Moustafa M.E., Sengupta A., Schweizer U., Shrimali R., Rao M., Zhong N., Wang S., Feigenbaum L., Lee B.J., Gladyshev V.N., Hatfield D.L. (2007) Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34. J Biol Chem., 282, 32591-32602. [Abstract] [Link]

Xu X.M., Carlson B.A., Zhang Y., Mix H., Kryukov G.V., Glass R.S., Berry M.J., Gladyshev V.N., Hatfield D.L. (2007) New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. Biol Trace Elem Res., 119, 234-241. [Abstract] [Link]

Shchedrina V.A., Novoselov S.V., Malinouski M.Y., Gladyshev V.N. (2007) Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif. Proc Natl Acad Sci U S A, 104, 13919-13924. [Abstract] [Link]

Zhang Y., Gladyshev V.N. (2007) High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis. Nucleic Acids Res., 35, 4952-4963. [Abstract] [Link]

Sal L.S., Aachmann F.L., Kim H., Gladyshev V.N., Dikiy A. (2007) NMR assignments of 1H, 13C and 15N spectra of methionine sulfoxide reductase B1 from Mus musculus. Biomol NMR Assign, 1, 131–133. [Abstract]

Su D., Berndt C., Fomenko D.E., Holmgren A., Gladyshev V.N. (2007) A Conserved cis-Proline Precludes Metal Binding by the Active Site Thiolates in Members of the Thioredoxin Family of Proteins. Biochemistry, 46, 6903-6910. [Abstract]

Dikiy A., Novoselov S.V., Fomenko D.E., Sengupta A., Carlson B.A., Cerny R.L., Ginalski K., Grishin N.V., Hatfield D.L., Gladyshev V.N. (2007) SelT, SelW, SelH, and Rdx12: Genomics and Molecular Insights into the Functions of Selenoproteins of a Novel Thioredoxin-like Family. Biochemistry, 46, 6871-6882. [Abstract]

Novoselov S.V., Lobanov A.V., Hua D., Kasaikina M.V., Hatfield D.L., Gladyshev V.N. (2007) A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells. Proc Natl Acad Sci U S A, 104, 7857-7862. [Abstract] [Link] [Supporting Information]

Yoo M.H., Xu X.M., Turanov A.A., Carlson B.A., Gladyshev V.N., Hatfield D.L. A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR. RNA, 13, 921-929. [Abstract]

Koc A., Gladyshev V.N. Methionine sulfoxide reduction and the aging process. Ann N Y Acad Sci, 1100, 383-386. [Abstract]

Labunskyy V.M., Hatfield D.L., Gladyshev V.N. (2007) The Sep15 protein family: Roles in disulfide bond formation and quality control in the endoplasmic reticulum. IUBMB Life, 59, 1-5. [Abstract]

Xu X.M., Carlson B.A., Irons R., Mix H., Zhong N., Gladyshev V.N., Hatfield D.L. (2007) Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis. Biochem J., 404, 115-20. [Abstract] [Link]

Novoselov S.V., Kryukov G.V., Xu X.M., Carlson B.A., Hatfield D.L., Gladyshev V.N. (2007) Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. J Biol Chem., 282,11960-11968. [Abstract] [Link]

Grossman A.R., Croft M., Gladyshev V.N., Merchant S.S., Posewitz M.C., Prochnik S., Spalding M.H. (2007) Novel metabolism in Chlamydomonas through the lens of genomics. Curr Opin Plant Biol., 10, 190-198. [Abstract] [Link]

Fomenko D.E., Xing W., Adair B.M., Thomas D.J., Gladyshev V.N. (2007) High-Throughput Identification of Catalytic Redox-Active Cysteine Residues. Science, 315, 387-389. [Abstract] [Full text] [Link] [Supporting Online Material]

Mix H., Lobanov A.V., Gladyshev V.N. (2007) SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes. Nucleic Acids Res., 35, 414-423. [Abstract] [Link] [Supplementary Material]

Shrimali R.K., Weaver J.A., Miller G.F., Starost M.F., Carlson B.A., Novoselov S.V., Kumaraswamy E., Gladyshev V.N., Hatfield D.L. (2007) Selenoprotein expression is essential in endothelial cell development and cardiac muscle function. Neuromuscul Disord., 7, 135-142. [Abstract]

Xu X.M., Carlson B.A., Mix H., Zhang Y., Saira K., Glass R.S., Berry M.J., Gladyshev V.N., Hatfield D.L. (2007) Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes. PLoS Biol., 5, e4. [Abstract] [Link]

Kim H.Y., Fomenko D.E., Yoon Y.E., Gladyshev V.N. (2006) Catalytic Advantages Provided by Selenocysteine in Methionine-S-Sulfoxide Reductases. Biochemistry, 45, 13697-13704. [Abstract]

Fernando M.R., Lechner J.M., Lofgren S., Gladyshev V.N., Lou M.F. (2006) Mitochondrial thioltransferase (glutaredoxin 2) has GSH-dependent and thioredoxin reductase-dependent peroxidase activities in vitro and in lens epithelial cells. FASEB J., 20, 2645-2647. [Abstract]

Selenium: Its molecular biology and role in human health (ed., Hatfield, D. L., Berry, M. J., Gladyshev, V. N.) Springer, pp. 419, 2006 [Purchase] [Preface]

Zhang Y., Romero H., Salinas G., Gladyshev V.N. (2006) Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox-active cysteine residues. Genome Biology , 7, R94. [Abstract] [Link]

Lobanov A.V., Gromer S., Salinas G., Gladyshev V.N. (2006) Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein. Nucleic Acids Res, 34, 4012-4024. [Abstract] [Link]

Hatfield D.L., Carlson B.A., Xu X.M., Mix H., Gladyshev V.N. (2006) Selenocysteine incorporation machinery and the role of selenoproteins in development and health. Prog Nucleic Acid Res Mol Biol., 81, 97-142. [Abstract]

Turanov A.A., Su D., Gladyshev V.N. (2006) Mouse mitochondrial thioredoxin reductase: Characterization of alternative cytosolic forms and cellular targets. J Biol Chem, 281, 22953-22963. [Abstract] [Link]

Lobanov A.V., Kryukov G.V., Hatfield D.L., Gladyshev V.N. (2006) Is there a twenty third amino acid in the genetic code? Trends Genet., 22, 357-360. [Abstract] [Link]

Eckenroth B., Harris K., Turanov A.A., Gladyshev V.N., Raines R.T., Hondal R.J. (2006) Semisynthesis and Characterization of Mammalian Thioredoxin Reductase. Biochemistry, 45, 5158-5170. [Abstract]

Yoo M.H., Xu X.M., Carlson B.A., Gladyshev V.N., Hatfield D.L. (2006) Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. J Biol Chem, 281, 13005-13008. [Abstract] [Link]

Kim H.Y., Gladyshev V.N. (2006) Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases.
BMC Mol Biol., 7, 11. [Abstract] [Link]

Lobanov A.V., Delgado C., Rahlfs S., Novoselov S.V., Kryukov G.V., Gromer S., Hatfield D.L., Becker K., Gladyshev V.N. (2006) The Plasmodium selenoproteome. Nucleic Acids Res., 34, 496-505. [Abstract] [Link]

Ferguson A.D., Labunskyy V.M., Fomenko D.E., Arac D., Chelliah Y., Amezcua C.A., Rizo J., Gladyshev V.N., Deisenhofer J. (2006) NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of new thioredoxin-like family. J Biol Chem, 281, 3536-3543. [Abstract]

Novoselov S.V., Hua D., Lobanov A.V., Gladyshev V.N. (2006) Identification and characterization of Fep15, a new selenocysteine-containing member of the Sep15 protein family. Biochem J, 394, 575-579. [Abstract] [Link]

Kim H.Y., Gladyshev V.N. (2005) Different Catalytic Mechanisms in Mammalian Selenocysteine- and Cysteine-Containing Methionine-R-Sulfoxide Reductases. PLoS Biol., 3, e375. [Abstract] [Link]

Sun Q.A., Su D., Novoselov S.V., Carlson B.A., Hatfield D.L., Gladyshev V.N. (2005) Reaction mechanism and regulation of Mammalian thioredoxin/glutathione reductase. Biochemistry, 44, 14528-14537. [Abstract]

Castellano S., Lobanov A.V., Chapple C., Novoselov S.V., Albrecht M., Hua D., Lescure A., Lengauer T., Krol A., Gladyshev V.N, Guigó R. (2005) Diversity and functional plasticity of eukaryotic selenoproteins: Identification and characterization of the SelJ family. Proc Natl Acad Sci, 102, 16188-16193. [Abstract]

Xu X.M., Mix H., Carlson B.A., Grabowski P.J., Gladyshev V.N., Berry M.J., Hatfield D.L. (2005) Evidence for direct roles of two additional factors, SECp43 and SLA, in the selenoprotein synthesis machinery. J Biol Chem, 280, 41568-41575. [Abstract]

Biterova E.I., Turanov A.A., Gladyshev V.N., Barycki J.J. (2005) Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. Proc Natl Acad Sci, 102, 15018-15023. [Abstract]

Novoselov S.V., Calvisi D.V., Labunskyy V.M., Factor V.M., Carlson B.A., Fomenko D.E., Moustafa M.E., Hatfield D.L. and Gladyshev V.N. (2005) Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene, 24, 8003-8011. [Abstract]

Labunskyy V.M., Ferguson A.D., Fomenko D.E., Chelliah Y., Hatfield D.L., Gladyshev V.N. (2005) A novel cysteine-rich domain of SEP15 mediates the interactions with UDP-glucose: Glycoprotein glucosyltransferase. J Biol Chem., 280, 37839-37845. [Abstract]

Romero H., Zhang Y., Gladyshev V.N., Salinas G. (2005) Evolution of selenium utilization traits. Genome Biol., 6, R66. [Abstract] [Link]

Kim H.Y., Gladyshev V.N. (2005) Role of structural and functional elements of mouse methionine-s-sulfoxide reductase in its subcellular distribution. Biochemistry, 44, 8059-8067. [Abstract]

Su D., Novoselov S.V., Sun Q.A., Moustafa M.E., Zhou Y., Oko R., Hatfield D.L., Gladyshev V.N. (2005) Mammalian selenoprotein thioredoxin/glutathione reductase: Roles in disulfide bond formation and sperm maturation. J Biol Chem., 280, 26491-26498. [Abstract] [Link]

Su D., Li Y., Gladyshev V.N. Selenocysteine insertion directed by the 3'-UTR SECIS element in Escherichia coli. (2005) Nucleic Acids Res., 33, 2486-2492. [Abstract]

Taskov K., Chapple C., Kryukov G.V., Castellano S, Lobanov A.V., Korotkov K.V., Guigó R. and Gladyshev V.N. Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome? (2005) Nucleic Acids Research, 33, 2227-2238. [Abstract] [Full text] [Link]

Zhang Y., Fomenko D.E., Gladyshev V.N. The microbial selenoproteome of the Sargasso Sea. (2005) Genome Biology, 6, R37. [Abstract] [Link]

Zhang Y., Gladyshev V.N. An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes. (2005) Bioinformatics, 21, 2580-2589. [Abstract]

Zhang Y., Baranov P.V., Atkins J.F., Gladyshev V.N. Pyrrolysine and selenocysteine use dissimilar decoding strategies. (2005) J Biol Chem., 280, 20740-20751. [Abstract]

Shrimali R.K., Lobanov A.V., Xu X.M., Rao M., Carlson B.A., Mahadeo D.C., Parent C.A., Gladyshev V.N., Hatfield D.L. Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila (2005) Biochem Biophys Res Commun. 329, 147-151. [Abstract]

Carlson B.A., Xu X.M., Gladyshev V.N., Hatfield D.L. Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA.(2005) J Biol Chem. 280, 5542-5548. [Abstract]

Gladyshev V.N., Kryukov G.V., Fomenko D.E., Hatfield D.L. (2004) Identification of trace element-containing proteins in genomic databases. Annu Rev Nutr., 24, 579-596. [Abstract]

Wang C., Scott S., Tao Q., Fomenko D.E., Gladyshev V.N. (2004) New Techniques for Generation and Analysis of Evolutionary Trees. International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, 283-289. [Text]

Su D., Gladyshev V.N. (2004) Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1. Biochemistry, 43, 12177-12188. [Abstract]

Carlson B.A., Xu X.M., Kryukov G.V., Rao M., Berry M.J., Gladyshev V.N., Hatfield,D.L. (2004) Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Proc Natl Acad Sci U S A., 101, 12848-12853. [Abstract]

Kim H.Y., Gladyshev V.N. (2004) Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Biochem Biophys Res Commun., 320, 1277-1283. [Abstract]

Koc A., Gasch A.P., Rutherford J.C., Kim H.Y., Gladyshev V.N. (2004) Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci U S A., 101, 7999-8004. [Abstract]

Kryukov G.V., Gladyshev V.N. (2004) The prokaryotic selenoproteome. EMBO Rep., 5, 538-543. [Abstract] [Link]

Castellano S., Novoselov S.V., Kryukov G.V., Lescure A., Blanco E., Krol A., Gladyshev V.N., Guigo R. (2004) Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. EMBO Rep., 5, 71-77. [Abstract] [Link]

Kim H.Y., Gladyshev V.N. (2004) Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Mol Biol Cell., 15, 1055-1064. [Abstract] [Link]

Carlson B.A., Novoselov S.V., Kumaraswamy E., Lee B.J., Anver M.R., Gladyshev V.N., Hatfield D.L. (2004) Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem., 279, 8011-8017. [Abstract]

Fomenko D.E., Gladyshev V.N. (2003) Genomics perspective on disulfide bond formation. Antioxid Redox Signal., 5, 397-402. Review. [Abstract]

Kwon S.Y., Badenhorst P., Martin-Romero F.J., Carlson B.A., Paterson B.M., Gladyshev V.N., Lee B.J., Hatfield D.L. (2003) The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development. Mol Cell Biol., 23, 8495-8504. [Abstract]

Fomenko D.E., Gladyshev V.N. (2003) Identity and functions of CxxC-derived motifs. Biochemistry, 42, 11214-11225. [Abstract]

Thisse C., Degrave A., Kryukov G.V., Gladyshev V.N., Obrecht-Pflumio S., Krol A., Thisse B., Lescure A. (2003) Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns., 3, 525-532. [Abstract]

Rao M., Carlson B.A., Novoselov S.V., Weeks D.P., Gladyshev V.N., Hatfield D.L. (2003) Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec. RNA., 9, 923-930. [Abstract]

Kryukov G.V., Castellano S., Novoselov S.V., Lobanov A.V., Zehtab O., Guigo R, Gladyshev V.N. (2003) Characterization of mammalian selenoproteomes. Science, 300, 1439-1443. [Abstract] [Full text] [Link]

Kumaraswamy E., Carlson B.A., Morgan F., Miyoshi K., Robinson G.W., Su D., Wan, S., Southo, E., Tessaroll, L., Le, B J., Gladyshe, V.N., Hennighausen L., Hatfield D.L. (2003) Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium. Mol. Cell. Biol., 23, 1477-1488. [Abstract] [Link]

Novoselov S.V., Gladyshev V.N. (2003) Non-animal origin of animal thioredoxin reductases: Implications for selenocysteine evolution and evolution of protein function through carboxy-terminal extensions. Protein Sci., 12, 372-378. [Abstract]

Xu X.M., Carlson B.A., Grimm T.A., Kutza J., Berry M.J., Arreola R., Fields, K.H., Shanmugam I., Jeang K.T., Oroszlan S., Combs G.F., Marx P.A., Gladyshev V.N., Clouse K.A., Hatfield D.L. (2002) Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS. J. Acquir. Immune. Defic. Syndr., 31, 453-463. [Abstract]

Fomenko D.E., Gladyshev V.N. (2002) CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function. Protein Sci., 11, 2285-2296. [Abstract]

Kumar R.A., Koc A., Cerny R.L., Gladyshev V.N. (2002) Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase. J. Biol. Chem., 277, 37527-37535. [Abstract] [Link]

Novoselov S.V., Rao M., Onoshko N.V., Zhi H., Kryukov G.V., Xiang Y., Weeks D.P., Hatfield D.L., Gladyshev V.N. (2002) Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. EMBO J., 21, 3681-3693. [Abstract] [Full text (pdf)] [Link]

Kryukov G.V., Kumar R.A., Koc A., Sun Z., Gladyshev V.N. (2002) Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc. Natl. Acad. Sci. USA, 99, 4245-4250. [Abstract]

Korotkov K.V., Novoselov S.V., Hatfield D.L., Gladyshev V.N. (2002) Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Mol. Cell. Biol., 22, 1402-1411. [Abstract]

Gladyshev V.N. (2002) Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds. Proteins, 146, 149-152. [Abstract]

Kumaraswamy E., Korotkov K.V., Diamond A.M., Gladyshev V.N., Hatfield D.L. (2002) Genetic and functional analysis of mammalian Sep15 selenoprotein. Methods Enzymol., 347, 187-197.

Kryukov G.V., Gladyshev V.N. (2002) Mammalian Selenoprotein Gene Signature: identification and functional analysis of selenoprotein genes using bioinformatics methods. Methods Enzymol., 347, 84-100.

Hatfield D.L., Gladyshev V.N. (2002) How selenium has altered our understanding of the genetic code. Mol. Cell. Biol., 22, 3565-3576. [Link]

Sun Q., Gladyshev V.N. (2002) Redox regulation of cell signaling by thioredoxin reductase. Methods Enzymol., 347, 451-461. [Link]

Gladyshev V.N., Liu A., Novoselov S.V., Krysan K., Sun Q.-A., Kryukov V.M., Kryukov G.V., Lou M.F. (2001) Identification and characterization of a new mammalian glutaredoxin (thioltransferase) Grx2. J. Biol. Chem., 276, 30374-30380. [Abstract] [Link]

Martin-Romero F.J., Kryukov G.K., Lobanov A.V., Carlson B.A., Lee B.J., Gladyshev V.N., Hatfield D.L. (2001) Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility and mortality. J. Biol. Chem., 276, 29798-29804. [Abstract] [Link]

Moustafa M.E., Carlson B.A., El-Saadani M.A., Kryukov G.V., Sun Q.-A., Harney J.W., Hill K.E., Combs G.F., Feigenbaum L., Mansur D.B., Burk R.F., Berry M.J., Diamond A.M., Lee B.J., Gladyshev V.N., Hatfield D.L. (2001) Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine mutant selenocysteine tRNA transgenes. Mol. Cell. Biol., 21, 3840-3852. [Abstract] [Link]

Sun Q.-A., Kirnarsky L., Sherman S., Gladyshev V.N. (2001) Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc. Natl. Acad. Sci. USA, 98, 3673-3678. [Abstract]

Korotkov K.V., Kumaraswamy E., Zhou Y., Hatfield D.L., Gladyshev V.N. (2001) Association between the 15 kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells. J. Biol. Chem., 276, 15330-15336. [Abstract]

Hu Y.J., Korotkov K.V., Mehta R., Hatfield D.L., Rotimi C., Luke A., Prewitt T.E., Cooper R.S., Stock W., Vokes E.E., Dolan M.E., Gladyshev V.N., Diamond A.M. (2001) Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. Cancer Res., 61, 2307-2310. [Abstract]

Sun Q.-A., Zappacosta F., Factor V.M., Wirth P., Hatfield D.L., Gladyshev V.N. (2001) Heterogeneity within animal thioredoxin reductases: evidence for alternative first exon splicing. J. Biol. Chem., 276, 3106-3114. [Abstract] [Link]

Gladyshev V.N. (2001) Comparison of selenium-containing molybdoenzymes. In "Molybdenum and Tungsten. Their roles in biological systems". Metal Ions in Biological Systems, 39, 655-672.

Gladyshev V.N., Kryukov G.V. (2001) Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins. BioFactors, 14, 87-92. [Abstract]

Gladyshev V.N. (2001) Identity, evolution and functions of selenoproteins and selenoprotein genes. In "Selenium: its molecular biology and role in human health", ed., Hatfield D.L., Kluwer Academic Publishers, pp. 99-113.

Gladyshev V.N., Diamond D.L., Hatfield D.L. (2001) The 15 kDa selenoprotein (Sep15): functional studies and a role in cancer etiology. In "Selenium: its molecular biology and role in human health", ed., Hatfield D.L., Kluwer Academic Publishers, pp. 147-155. [Link]

Gladyshev V.N. (2001) Selenium in biology and human health: controversies and perspectives. In "Selenium: its molecular biology and role in human health", ed., Hatfield D.L., Kluwer Academic Publishers, pp. 313-317. [Link]

Gladyshev V.N., Hatfield D.L. (2001) Analysis of selenocysteine-containing proteins. Curr Protoc Protein Sci., 3, 3.8. [Abstract]

Kumaraswamy E., Malykh A., Korotkov K.V., Kozyavkin S., Hu Y., Moustafa M.E., Carlson B., Berry M.J., Lee B.J., Hatfield D.L., Diamond A.M., Gladyshev V.N. (2000) Structure-expression relationships of the 15 kDa selenoprotein gene: possible role of the protein in cancer etiology. J. Biol. Chem. 275, 35540-35547. [Abstract] [Link]

Kryukov G.V., Gladyshev V.N. (2000) Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing seventeen selenocysteine residues. Genes Cells, 5, 1049-1060. [Abstract]

Mansur D.B., Hao H., Gladyshev V.N., Korotkov K., Hu Y., Moustafa M.E., El-Saadani M.A. Carlson B.A., Hatfield D.L., Diamond A.M. (2000) Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines. Biochem. Pharm., 60, 489-497. [Abstract]

Kryukov G.V., Kryukov V.M., Gladyshev V.N. (1999) New Mammalian Selenocysteine-containing Proteins Identified with an Algorithm That Searches for Selenocysteine Insertion Sequence Elements. J. Biol. Chem., 274, 33888-33897. [Abstract]

Sun Q.A., Wu Y., Zappacosta F., Jeang K.T., Lee B.J., Hatfield D.L., Gladyshev V.N. (1999) Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J. Biol. Chem., 274, 24522-24530. [Abstract]

Gladyshev V.N., Krause M., Xu X.M., Korotkov K.V., Kryukov G.V., Sun Q.-A., Lee B.J., Wootton J.C., Hatfield D.L. (1999) Selenocysteine-containing thioredoxin reductase in C. elegans. Biochem. Biophys. Res. Commun., 259, 244-249. [Abstract]

Gladyshev V.N., Stadtman T.C., Hatfield D.L., Jeang K.-T. (1999) Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Proc. Natl. Acad. Sci. USA, 96, 835-839. [Abstract] [Link]