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University of Nebraska–Lincoln

Vadim Gladyshev Lab

Redox Biology - Selenium

DNA Helix in the Beadle Center

Welcome to Gladyshev Lab Website


Check out our latest paper!

Science paper

Some reviews and comments:


Areas of interest:

  • Thiol-based redox regulation and signaling

  • Identity and functions of selenocysteine-containing proteins

  • Mechanism of cancer prevention by selenium

  • Bioinformatics

  • Redox biology

  • Aging

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Latest news from the lab



Eukaryotic Selenoproteins and Selenoproteomes. Lobanov A.V., Hatfield D.L., Gladyshev V.N., Biochim Biophys Acta.,, May 25 [Epub ahead of print]

Comparative Genomics of Trace Elements: Emerging Dynamic View of Trace Element Utilization and Function. Zhang Y., Gladyshev V.N. Chem Rev..

A structure-based approach for detection of thiol oxidoreductases and their catalytic redox-active cysteine residues. Marino S.M., Gladyshev V.N. PLoS Comput Biol., 5(5):e1000383.

Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast. Kaya A., Karakaya H.C., Fomenko D.E., Gladyshev V.N., Koc A. Mol Cell Biol., May 4 [Epub ahead of print].

Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging. Shchedrina V.A., Vorbruggen G., Lee B.C., Kim H.Y., Kabil H., Harshman L.G., Gladyshev V.N. Mech Ageing Dev, Apr28 [Epub ahead of print].

Functions and evolution of selenoprotein methionine sulfoxide reductases. Lee B.C., Dikiy A., Kim H.Y., Gladyshev V.N. Biochim Biophys Acta, Apr 27 [Epub ahead of print]