Nebraska Redox Biology Center Educational Portal

Hydroperoxyl Radical

Hydroperoxyl radical is a protonated form of superoxide. About 0.3% of any superoxide present in the cytosol of a typical cell is in the protonated form. This radical is one of the most abundant free radicals in the atmosphere [ 1, 2, 3 ].

Hydroperoxyl radical is a precursor of hydrogen peroxide in chain of ROS formation. Very little is known about biologycal function of hydroperoxyl radical. This radical may be involved in redox signaling processes [ 2, 4 ].

A synthetic Cypridina luciferin analogue (CLA) luminescence is widely used for detection of hydroperoxyl in biological systems. The chemiluminescence spectrum depends on pH, peaking at 380 nm at pH 7.0 and 450 nm at pH 11.1 [ 5 ].

A mechanism for reaction of CLA with hydroperoxyl radical.

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